The Depot is the only remaining building left from the once large Union Pacific presence in Laramie and was added to the National Register of Historic Places in 1988. The railroad is the reason for the City's original existence, and the Depot is an important part of Laramie's historic legacy.

The building houses a museum of railroad memorabilia and is used for various community functions such as music concerts, art exhibits and public meetings. The building is also used to raise revenue to maintain itself through rentals for weddings, banquets and other events.

Free tours are available on Mondays from 9 am to 2pm, or by appointment. Additionally, the Depot periodically hosts open houses, model train exhibits, and other public events. More information can be found on the Depot's website and Facebook page.